Iloprost, a synthetic prostacyclin analog used as vasodilator to 治疗 pulmonary arterial hypertension (PAH), has been approved by the U.S. 食品 and Drug Administration for treatment of severe frostbite. This is first approved 药物治疗 in the USA to treat severe frostbite in adults to reduce the risk of amputation.
Frostbite is a serious condition that require immediate 医生 attention. It is caused due to exposure to freezing temperature long enough to allow ice crystals to form in the tissues. People working outdoors in cold regions such as security personals, industrial workers, mountaineers or hikers etc are usually affected by frostbite. Amputation of fingers and toes because of frostbite is common in such regions despite advances in 健康 护理服务。
伊洛前列素是一种合成的前列环素类似物。它逆转血管收缩并抑制血小板活化，充当血管舒张剂，打开血管并防止血液凝固。它于2004年首次被批准用于治疗肺动脉高压（PAH）。
Iloprost and thrombolytics are beneficial for treating frostbite. In Canada, 患者 with severe frostbite involving freezing of skin and underlying tissues and stoppage of blood flow have been successfully treated with iloprost. The old drug has now been approved by the U.S. Food and Drug Administration (FDA）用于治疗严重冻伤。
FDA 批准 Eicos Sciences Inc. 生产用于治疗严重冻伤的伊洛前列素，商品名为“Aurlumyn”。
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参考文献：
- FDA 批准第一种治疗严重冻伤的药物。发布于 14 年 2024 月 XNUMX 日。可在 https://www.fda.gov/news-events/press-announcements/fda-approves-first-medication-treat-severe-frostbite/
- Regli, IB、Oberhammer, R.、Zafren, K. 等人。冻伤治疗：系统评价与荟萃分析。 Scand J 创伤复苏急救医学 31, 96 (2023)。 https://doi.org/10.1186/s13049-023-01160-3
- Poole A. 和 Gauthier J. 2016。在加拿大北部用伊洛前列素治疗严重冻伤。 CMAJ 06 年 2016 月 188 日 17 (18-1255) 1258-XNUMX；数字编号： https://doi.org/10.1503/cmaj.151252
- 格鲁伯，E.，奥伯哈默，R.，布鲁格，H. 等人。长时间严重雪崩掩埋近 23 小时，伴有严重低温和严重冻伤，但恢复良好：病例报告。 Scand J 创伤复苏急救医学 32, 11 (2024)。 https://doi.org/10.1186/s13049-024-01184-3
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