研究人员研究了一种调节免疫细胞功能以治疗肥胖症的替代方法
Obesity is a chronic illness which affects 30% of the world’s total 人口。 的主要原因 肥胖 is higher consumption of fat rich 食品 and limited physical activity or exercise. The surplus amount of high energy consumed (mainly from fat and sugars) is then stored in the body as fat leading to high body weight. The Body Mass Index (BMI) of an obese person is very high between 25 and 30. Many factors affect and contribute to obesity like genetics, body’s metabolism rate, lifestyle, environmental factors etc. Obesity or high 身体 weight then leads to other negative outcomes in the body by causing harmful inflammation. Obese or overweight people are at a higher risk of developing severe illnesses or conditions, including heart disease because of clogged arteries, Type 2 糖尿病 和严重的骨骼和关节疾病。
在发表的一项研究 美国国家科学院院刊 阐明原因 免疫细胞 inside our fat tissue become harmful when someone is suffering from obesity. These immune cells in our body otherwise considered to be useful start to cause undesired inflammation and changes in the metabolic system. Free radicals are produced in our body during normal metabolic processes or due to exposure to outside sources like harmful radiation, smoking, environmental pollution etc. The free radicals are unstable and harmful atoms which can damage cells in our body and cause ageing and illness. Researchers from University of Virginia School of Medicine say that these free radicals are highly reactive in an obese person as they react with lipids inside the fat tissue. Once lipids – which are considered an attractive target by the free radicals – combine with free radicals, normal immune response occurs in the body causing inflammation and results in ‘lipid oxidation’. The small oxidized lipids are pretty harmless and are found in healthy cells. However, longer full length oxidized lipids, found generally in obese tissue cause excessive harmful inflammation which propagates the obesity 疾病 within the fat tissue.
The knowledge of these problematic oxidized lipids can be used to devise a method to block them which can then prevent harmful inflammation. Example, a 药物 which could either diminish or completely eliminate longer and damaging oxidized lipids. Such a therapy would be extremely beneficial for a chronic disease like obesity. However, as scientists point out, eradicating all inflammation may not be the right approach because some of it is useful for the body. Targeting metabolics of immune cells in our immune system is an approach which is already being used for cancer.
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来源（S）
Serbulea V 等。 2018. 巨噬细胞表型和生物能量学受瘦和肥胖脂肪组织中鉴定的氧化磷脂控制。 诉讼中的国家科学院院士. 115（27）。
https://doi.org/10.1073/pnas.1800544115
